Characteristics and Advantages of the PCMC Platform - Water adsorption - The PCMC particles adsorb very low level of water therefore the particles do not aggregate under stress humidity conditions but remain as fine free-flowing powders.
- A scaleable process - XstalBio has demonstrated that the manufacturing process is rapid, robust, with reproducible production of sterile material for both pulmonary and parenteral applications. Low capital costs compared to freeze-drying and spray-drying make this process an alternative and competitive technology to freeze-drying and spray-drying.
- Payload versatility - The active loading on the crystal surface can be altered to provide the appropriate dosing regime.
| - Stability - Studies using a range of client therapeutic molecules, of various sizes and hydrophobicities, have shown that the proteins show excellent retention of activity and a very low level of protein aggregation (> 98 % and < 2 % respectively) when exposed to accelerated stress conditions.
- Particle morphology - No change upon hydration.
- Fine Particle Fraction (FPF) - High fine particle fractions routinely achieved using a range of microcrystal carriers as determined by multi-stage liquid impinger (MSLI) and TSI measurements.
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