Solid State Circular DichroismA recognised problem for most analytical tools that are based on spectroscopic techniques is that up until now it has not been possible to analyse protein-based products in the solid-state due to artefacts associated with scattering.
“Application of the Drug Product CD analysis technique to our drug product has fundamentally changed our understanding of the formulation. This has resulted in the identification of technology options for formulation improvement."
Dr Allan Watkinson, Vaccines R&D Director, Avecia Biotechnology XstalBio can provide biotechnology, pharmaceutical and vaccine companies interested in the delivery and stabilisation of proteins or vaccines an immediate competitive advantage by offering a significant advancement in Circular Dichroism (CD) analysis. Conventional CD is used to elucidate the structural aspects of protein conformation in solution but cannot be applied to particles. An innovative, yet simple, rotating CD cell holder has been developed by XstalBio to provide rapid, reliable information on the secondary and tertiary structure of proteins in the solid-state, for example: - bound onto particles such as alhydrogel or encapsulated into lipid membranes.
- as solvent suspensions of lyophilised powders.
- in solution in the presence of scattering particles or aggregates.
XstalBio has already completed successful technology transfer of this technique to a major pharmaceutical company active in vaccine development and a large biotechnology company. View example spectra for a vaccine formulation or contact us for more information.
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